
OTS514 hydrochloride(1338540-63-8(free base))
CAS No. 2319647-76-0
OTS514 hydrochloride(1338540-63-8(free base))( OTS-514 hydrochloride )
Catalog No. M24060 CAS No. 2319647-76-0
OTS514 is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 88 | In Stock |
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5MG | 159 | In Stock |
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10MG | 291 | In Stock |
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25MG | 527 | In Stock |
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50MG | 710 | In Stock |
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100MG | 897 | In Stock |
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500MG | 1791 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameOTS514 hydrochloride(1338540-63-8(free base))
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NoteResearch use only, not for human use.
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Brief DescriptionOTS514 is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).
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DescriptionOTS514 is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).
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In VitroOTS514 (1.5625-100 nM) induces cell cycle arrest and apoptosis at nanomolar concentrations in a series of human myeloma cell lines (HMCL) and prevents outgrowth of a putative CD138+ stem cell population from multiple myeloma (MM) patient-derived peripheral blood mononuclear cells. Cell Viability Assay Cell Line:Human myeloma cell lines (MM1.S, MM1.R, RPMI 8226, 8226Dox40, KMS34, KMS34CFZ, KMS11, JJN3, LP-1, NCI H929, U266B1) Concentration:1.5625, 3.125, 6.25, 12.5, 25, 50, and 100 nM Incubation Time:72 hours Result:IC50 values ranged from 11.6 to 29.4 nM in parental cell lines, indicating a potent inhibitory effect. Only the RPMI 8226-Dox40 cell line, which overexpresses the multi-drug resistance transporter gene ABCB1, was resistant.
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In VivoOTS514 (1-5 mg/kg; once a day for 2 weeks; intravenous administration) induces tumor regression in a xenograft model of A549 cells (TOPK-positive lung cancer cells). Animal Model:Female BALB/cSLC-nu/nu mice bearing a xenograft model of A549 cellsDosage:1, 2.5, and 5 mg/kgAdministration:Intravenously treated; once every day for 2 weeks Result:Resulted in tumor growth inhibition (TGI) of 5.7, 43.3, and 65.3% on day 15, respectively, without any body weight loss.
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SynonymsOTS-514 hydrochloride
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PathwayOthers
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TargetOther Targets
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RecptorTOPK
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Research Area——
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Indication——
Chemical Information
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CAS Number2319647-76-0
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Formula Weight400.92
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Molecular FormulaC21H20N2O2S.HCl
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESCl.C[C@@H](CN)c1ccc(cc1)-c1c(O)cc(C)c2[nH]c(=O)c3sccc3c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference



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